This study explores the relationship between methamphetamine dependence and domestic violence among male police detainees interviewed as part of the Drug Use Monitoring in Australia program.Detainees who were dependent on methamphetamine reported high rates of domestic violence. They were significantly more likely to have been violent towards an intimate partner in the previous 12 months than detainees who used methamphetamine but were not dependent. Similar patterns were observed for detainees who reported cannabis dependence. Attitudes minimising the impact of violence were also associated with an increased likelihood of domestic violence.The results illustrate the importance of integrated responses that address the co-occurrence of substance use disorders and domestic violence, and the underlying risk factors for both harmful behaviours.