The COVID-19 outbreak is impacting societies around the world in an unprecedented manner. However, not everyone, in every place, will be affected in the same way. Considering how the pandemic affects particular groups will help raise the effectiveness of containment efforts and minimize the potential negative impacts. This note focuses on one of such groups: Women and girls. Experiences from previous pandemics1 show that they can be especially active actors for change, while they can also experience the effects of the crisis in different (and often more negative) ways. Given that the COVID-19 is not gender-blind, the response to it should not be either. Based on the existing evidence and emerging trends the note summarizes key gender differentiated transmission channels and impacts on outcomes across the three areas of endowments, economic conditions, and agency. It also provides recommendations for action (see Table 1). This is a living document, to be completed as more data and analysis are made available.